MEMORANDUM OF INTENT
Between
the European Malaria Vaccine Initiative (EMVI),
and
the World Health Organization (WHO)

WHEREAS, malaria is a major public health problem in more than ninety (90) countries inhabited by approximately forty percent (40%) of the world's population;

WHEREAS, the mission of EMVI is to accelerate the development of malaria vaccines and ensure their availability and accessibility for the developing world;

WHEREAS, the objective of WHO is the attainment by all peoples of the highest possible level of health; and

WHEREAS, through its Initiative for Vaccine Research (IVR) and its Special Programme for Research and Training in Tropical Diseases (TDR), WHO promotes the development of new or improved, safe and effective vaccines for inter alia malaria, and the availability of such vaccines to the public, including the public sector of developing countries on preferential terms.

WHO and EMVI wish to collaborate to enhance the work, which each organization has in common and thereby promote the development of a malaria vaccine for use in disease endemic developing countries.

In connection with the foregoing, EMVI and WHO wish, where possible and appropriate, to collaborate in the following areas:

1. Exchange of information on programmatic matters relating to malaria vaccine development
2. Design and development of candidate malaria vaccines, e.g. design of clinical trials, choice of clinical trial endpoints, and training of, and other support for, field sites
3. Exchange and discussion of product information and pre-clinical and clinical trial results on candidate malaria vaccines, where permitted, and with due regard to obligations of confidentiality and restrictions on use
4. Strategic planning of candidate malaria vaccine development approaches

Any collaboration as aforesaid shall be subject to the availability of funds and each party's internal rules, regulations, policies, administrative procedures and practices. Each collaborative project shall thus be agreed on a case by case basis, subject to a separate exchange of letters or agreements, and could be implemented through any of the following:

1. Separate programming and funding, post facto reporting
2. Separate programming and funding, early coordination of effort
3. Joint programming, separate funding
4. Joint programming, pooled funding

It is acknowledged that each party may possess confidential information, which is proprietary to it or to third parties collaborating with it. Any such information shall only be shared between the parties under a separate confidential disclosure agreement, specifically covering such information.

This Memorandum of Intent is a non-binding statement of intent, which creates no rights and imposes no obligations on either party with regard to specific collaborative projects. The intentions of the parties are subject the continuing mutual agreement of the parties to undertake specific actions.

Any dispute relating to the interpretation or application of this Memorandum of Intent shall, unless amicably settled, be subject to conciliation. In the event of failure of the latter, the dispute shall be settled by arbitration. The arbitration shall be conducted in accordance with the modalities to be agreed upon by the parties, or in the absence of agreement, with the rules of arbitration of the International Chamber of Commerce. The parties shall accept the arbitral award as final.

For EMVI                                                 For WHO

By:                                                            By:
Renée van Kessel Hagersteijn                 Dr. Marie-Paule Kieny
Chairperson, EMVI                                   Director, IVR
February 2003                                         January 2003

For TDR

By:
Dr. Carlos Morel
Director, TDR
January 2003