Inventor:                                       Dr Alan Thomas,BPRC, Rijswijk
Product Leader:                             Florence Xhonneux, Eurogentec, Seraing
Clinical Trial Principal Investigator:  Prof Robert Sauerwein, RUNMC University of Nijmegen

Sponsored by EMVI
Assessment of the Safety and Immunogenicity of three Formulations of the Recombinant Pichia pastoris Apical Membrane Antigen 1 (PfAMA-1-FVO[25-545]), Blood-stage malaria Vaccine in Healthy Dutch Adult Volunteers: a Phase 1, Single-Blind, Randomised, Dose-escalating, Unicentre trial.

Trial registration: Clinicaltrials.gov NCT00730782.

A paper on the production of AMA1 FVO has been published in Vaccine. 2008 Nov 11;26(48):6143-50
A paper on the clinical trial has been published in Plos one, December 2008, volume 3(12):e3960.

Clinical development was stopped in 2008 to pursue the Diversity Covering (DiCo) approach which addresses the allele diversity.